期刊论文

Effects of extracts from Zhuanggu Zhitong formula on expression of bone density and bone biomechanics in ovariectomized rats

中文

山西中医药大学学报

2096-7403

2014

3

17-19

10.3969/j.issn.1000-7369.2014.03.008

2014年湖南省教育厅科学研究优秀青年项目（14B130）； 2008年国家自然科学基金面上项目（30873291）； 2012年度湖南省大学生研究性学习和创新性实验计划资助项目（2012-535）； 湖南省重点学科中西医结合基础资助； 湖南中医药大学重点学科病理学及病理生理学资助；

本校为第一机构

目的：观察壮骨止痛方对双侧卵巢摘除（去势法）后雌性大鼠骨密度及骨生物力学的影响。方法：60只雌性SD大鼠随机分为空白组、假手术组、模型组、壮骨止痛方全方组，每组15只。术后1w开始灌胃给药，连续13w。13w后按要求处死动物，观察雌性大鼠去势后骨质疏松模型骨密度及左后肢胫骨生物力学的变化。结果：壮骨止痛方能增加大鼠骨密度、胫骨最大应力和最大抗弯强度，与模型组比较差异有统计学意义。结论：壮骨止痛方具有抗骨质疏松的作用。

Objective:To observe effect of extracts from Zhuanggu Zhitong formula on bone mineral density and bone biome-chanics of female rats with bilateral ovaries resection (ovariectomy). Methods:60 female SD rats were randomly separated into blank group,sham-operated group,model group and Zhuanggu Zhitong formula group with 15 rats in each group. Cas-trated female rats model were made by ovariectomy,then were killed after 13 weeks′ feeding. Finally,the changes of bone mineral density and bone biomechanics of castrated female rats were observed. Resul...