期刊论文

Chen Xiang-Dong<&wdkj&>Peng Qing-Hua

中文

数字中医药(英文)

2096-479X

2019

2

1

19-28

10.1016/j.dcmed.2019.05.003

We thank for the funding support from the Provincial Natural Science Foundation General Program (No. 2015JJ2109 ), Hunan Province Graduate Student Research Innovation Program (No. CX2018B473 ), Hunan Traditional Chinese Medicine Scientific Research Program (NO. 201463 and NO. 2017141 ), Key Scientific Research Project of Hunan Administration of Traditional Chinese Medicine (NO. 201917 ), University-level Scientific Research Projects of Hunan University of Chinese Medicine (NO. 2017029 and NO. 2018XJJJ31 ), The Domestic First- class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Central Finance Supported Local High School Construction Project, State Administration of Traditional Chinese Medicine Ophthalmology Key Discipline Construction Project, Hunan Province Traditional Chinese Medicine Facial Feature Key Discipline Construction Project, Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine, Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine .

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目的探究养阴清热、活血利水之丹黄明目汤对糖尿病视网膜病变激光术后VEGF/PEDF调节机制的研究。方法将40只雄性棕色挪威（Brown Norway,BN）大鼠随机分为空白组（A组,10只）和模型组（30只）。采用40 mg/kg STZ腹腔注射诱导模型组大鼠建立DR模型,监测大鼠的体重和血糖,12周后进行FFA检查及血清P-Selectin、cAMP、c GMP的测定,经HE染色后光镜下观察视网膜组织形态,确认成功建立DR模型。所有模型组大鼠右眼行视网膜氩激光光凝,左眼不行激光光凝。将模型组随机分为B组（模型对照组）、C组（阳性对照组）、D组（丹黄明目汤组）,每组10只大鼠。A组和B组予蒸馏水灌胃,C组予羟苯磺酸钙悬浮液灌胃,D组予...

Objective: To analyze the effects of Dan Huang Ming Mu Recipe (DHMMR) (a pharmaceutical preparation from herbs and having the function of replenishing vital essence, removing heat, promoting blood circulation and excreting pathogenic water) on diabetic retinopathy (DR) after retinal laser photocoagulation through regulating the expression of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF). Methods: Forty male Brown Norway (BN) rats were randomly divided into blank group (group A, 10 BN rats) and model grou...