A polymer scaffold with drug-sustained release and antibacterial activity

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成果类型：

期刊论文

作者：

Wu, Ping;Hu, Shi;Liang, Qin;Guo, Wang;Xia, Yang;...

通讯作者：

Shuai, Cijun;Li, Yongmin

作者机构：

[Wu, Ping] Xiangtan Univ, Sch Chem Engn, Dept Pharmaceut Engn, Xiangtan, Peoples R China.

[Hu, Shi; Xia, Yang; Liang, Qin; Wu, Ping] Xiangtan Univ, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Xiangtan, Peoples R China.

[Guo, Wang; Shuai, Cijun] Cent S Univ, Coll Mech & Elect Engn, State Key Lab High Performance Complex Mfg, 932 South Lushan Rd, Changsha 410083, Hunan, Peoples R China.

[Shuai, Cijun] Jiangxi Univ Sci & Technol, Ganzhou, Peoples R China.

[Li, Yongmin] Hunan Acad Tradit Chinese Med Affiliated Hosp, Hunan Key Lab Chinese Med Oncol, Changsha, Peoples R China.

通讯机构：

[Shuai, Cijun] C

[Li, Yongmin] H

Cent S Univ, Coll Mech & Elect Engn, State Key Lab High Performance Complex Mfg, 932 South Lushan Rd, Changsha 410083, Hunan, Peoples R China.

Hunan Acad Tradit Chinese Med Affiliated Hosp, 58 Lushan Rd, Changsha 410083, Hunan, Peoples R China.

语种：

英文

关键词：

Antibacterial activity;drug-sustained release;polymer scaffold;total alkaloids from Semen Strychnine

期刊：

International Journal of Polymeric Materials and Polymeric Biomaterials

ISSN：

0091-4037

年：

2020

卷：

期：

页码：

398-405

DOI：

10.1080/00914037.2019.1581194

基金类别：

This work was technically supported by the following organization: Hunan Key Laboratory of Environment Friendly Chemical Process Integration Technology, National & Local United Engineering Research Centre for Chemical Process Simulation and Intensification, National Department of Education Engineering Research Centre for Chemical Process Simulation, Collaborative Innovation Center of New Chemical Technologies for Environmental Benignity Optimization and Efficient Resource Utilization, Hunan Key Laboratory of Chinese medicine oncology [2017TP1033] and Innovative platform of antitumor Chinese drugs [2018CT5005], and financially supported by the following founds: (1) the Natural Science Foundation of China [51575537]; (2) China Scholarship Council (CSC) for the State Scholarship Fund [No. 201708430071] program; (3) Xiangtan University start-up grant [16QDZ33] and Xiangtan University grant [16XZX17].

机构署名：

本校为通讯机构

摘要：

Total alkaloids from Semen Strychnine (TASS), as an antibacterial drug, was loaded into polyetheretherketone (PEEK)/polyglycolide acid (PGA) scaffolds fabricated via 3 D printing technology. It focused on studying microstructure, drug-release behavior, antibacterial activity and biocompatibility of scaffolds. Results indicated that TASS had a good physiochemical compatibility with polymer matrix, and a sustained release for longtime in TASS-PEEK/PGA scaffolds. Moreover, the scaffolds manifested antimicrobial activity against E. coli and S. aure...

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A polymer scaffold with drug-sustained release and antibacterial activity

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