期刊论文

Treatment with Xiaochaihu decoction increases serum levels of motiUn and gastrin in rats with dyspepsia

Yu, B.-S.

中文

世界华人消化杂志

1009-3079

2013

21

5

440-444

10.3748/wcjd.v21.i5.440

长沙市科技计划重点基金资助项目,No.k1005020-31； 湖南省教育厅基金资助项目,No.06C629~~；

本校为第一且通讯机构

目的:观察小柴胡汤对消化不良模型大鼠(肝郁脾虚型)胃肠激素中胃动素(motilin,MTL)和胃泌素(gastrin,GAS)的影响,分析其治疗消化不良的作用机制.方法:将48只大鼠随机分为4组,每组12只,分别为:空白组、模型组、小柴胡汤组和多潘立酮组.除空白组外其余3组均采用复合病因造模法(慢性束缚应激+过度疲劳+饮食失节)造模,连续21 d后造模结束.再按被试因素施加方法每天进行生理盐水、小柴胡汤、多潘立酮灌胃14 d.实验第35天给药结束后,禁食不禁水24 h,于实验第36天,取血清进行检测.结果:(1)与空白组相比,模型组实验大鼠的血清MTL含量明显降低,差异有高度统计学意义(P=0.00＜0.01);与模型组相比,小柴胡汤...

AIM: To observe the influence of treatment with Xiaochaihu decoction on serum levels of motilin (MTL) and gastrin (GAS) in a rat model of dyspepsia (syndrome of liver-qi stagnation and spleen-qi deficiency) and to analyze the mechanisms behind therapeutic effects of Xiaochaihu decoction on dyspepsia. METHODS: Forty-eight rats were randomly divided into four groups (n = 12 for each): blank group (BG), model group (MG), Xiaochaihu decoction group (XG), and domperidone group (DG). Except the BG group, dyspepsia was induced in rats of the other thr...