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HS-GC-IMS-Based metabonomics study of Baihe Jizihuang Tang in a rat model of chronic unpredictable mild stress

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成果类型:
期刊论文
作者:
Yuan, Zhi-ying;Li, Jing;Zhou, Xiao-jiang;Wu, Min-hui;Li, Liang;...
通讯作者:
Xie, Men-zhou;Huang, HY
作者机构:
[Xie, Men-zhou; Huang, Hui-yong; Li, Liang; Chen, Nai-hong; Yuan, Zhi-ying; Zhou, Xiao-jiang; Li, Jing; Pei, Gang; Liu, Kai-li; Wu, Min-hui] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.
[Chen, Nai-hong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China.
[Xie, Men-zhou; Yuan, Zhi-ying; Huang, Hui-yong] Hunan Engn Technol Ctr Funct Food Homol Med, Changsha 410208, Peoples R China.
[Yuan, Zhi-ying; Zhou, Xiao-jiang; Pei, Gang] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Peoples R China.
通讯机构:
[Xie, MZ; Huang, HY ] H
Hunan Univ Chinese Med, Changsha 410208, Peoples R China.
语种:
英文
关键词:
Biomarkers;Diagnosis;Discriminant analysis;Gas chromatography;Ion chromatography;Ion mobility spectrometers;Least squares approximations;Multivariant analysis;Rats;Volatile organic compounds;Clinical treatments;Headspace gas chromatography;Ion mobility spectrometry;Multivariate statistical analysis;Partial least squares - discriminant analysis;Relative peak intensity;Therapeutic effects;Traditional Chinese Medicine;Principal component analysis;2 butanone;2 pentylfuran;antidepressant agent;Baihe jizihuang tang;Chinese drug;dimethyltrisulfide;hydroxyacetone;methional;nonanal;nonanol;phenethyl alcohol;phenylacetaldehyde;propionic acid;trimethylpyrazine;unclassified drug;volatile organic compound;animal experiment;animal model;Article;Chinese medicine;chronic unpredictable stress;controlled study;depression;derivatization;discriminant analysis;feces;gas chromatography;headspace gas chromatography ion mobility spectrometry;ion mobility spectrometry;male;metabonomics;multivariate analysis;nonhuman;partial least squares regression;principal component analysis;priority journal;rat;therapy effect
期刊:
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
ISSN:
1570-0232
年:
2020
卷:
1148
页码:
122143
基金类别:
This work was supported by the Foundation for Key Project of Changsha Municipal Bureau of Science and Technology (kq1801044), the Youth Program of the Natural Science Foundation of Hunan Province (2019JJ50446), the Foundation for Project of Scientific Research Plan of Traditional Chinese Medicine in Hunan Province (202069, 202108), and the Innovation Project of Graduate Students of Hunan University of Chinese Medicine (2018CX03). This work was supported by the Foundation for Key Project of Changsha Municipal Bureau of Science and Technology ( kq1801044 ), the Youth Program of the Natural Science Foundation of Hunan Province ( 2019JJ50446 ), the Foundation for Project of Scientific Research Plan of Traditional Chinese Medicine in Hunan Province ( 202069 , 202108 ), and the Innovation Project of Graduate Students of Hunan University of Chinese Medicine ( 2018CX03 ).
机构署名:
本校为第一且通讯机构
摘要:
The aim of this study was to investigate the differences in volatile organic compounds (VOCs) obtained from the feces of a Baihe Jizihuang Tang (BHT)-treated rat depression model. Rats were subjected to chronic unpredictable mild stress (CUMS), and the differences in VOCs were analyzed by headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS), NIST software, principal component analysis, and orthogonal partial least squares discriminant analysis. Eleven biomarkers were identified on the basis of VOC migration time, and their relativ...

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