期刊论文

Study on the expression of HLA-G on lymphocytes and serum TGF-β,IL-10 levels in hepatocellular carcinoma patients

中文

武警后勤学院学报(医学版)

2095-3720

2014

23

6

468-470

10.3969/j.issn.2095-3720.2014.06.003

本校为第一机构

[目的]研究肝癌患者外周血淋巴细胞HLA-G分子表达及血清TGF-β,IL-10水平,探讨其在肝癌发生发展过程中的相关性.[方法]收集44例肝细胞癌患者,21例肝硬化患者和40例健康查体者外周血,流式细胞术考察其HLA-G分子表达情况,ELISA检测其血清TGF-β,IL-10水平.[结果]肝癌组、肝硬化组和健康组HLA-G分子表达率分别为43.2％,14.2％和10.0％,肝癌组高于另2组,差异有统计学意义(P＜0.05).肝癌组淋巴细胞HLA-G分子主要表达于CD4+细胞上.肝癌组TGF-β水平(773.01±398.69) ng/L、IL-10水平(19.58±10.78) ng/L高于肝硬化组(380.41±265.33) ng/L、(13.91±6.58) ng/L和健康组(379.68±203.75) ng/L、(10.09±...

【Objective】 To study the expression of HLA-G in lymphocyte and serum levels of TGF- β,IL-10 in liver cancer patients,and explore its relationship with tumorigenesis.【Methods】 Peripheral hlood of 44 cases of hepatocellular carcinoma（HCC）,21 cases of liver cirrhosis and 40 healthy subjects were taken and mesured by flow cytometry and their serum TGF- β,IL-10 levels were measured by ELISA.【Results】The HLA-G expression rates in HCC group,liver cirrhosis group and healthy group were 43.2%,14.2%and 10%respectively.HCC group was higher than ...