UVB irradiation differential regulate miRNAs expression in skin photoaging

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成果类型：

期刊论文

作者：

Fang, Yuan;Chen, Lei;Wang, Xin;Li, Xu;Xiong, Wu;...

通讯作者：

Haibo Li<&wdkj&>Jianda Zhou

作者机构：

[Li, Haibo; Li, Xu; Zhou, Jianda; Chen, Lei; Cao, Ke; Fang, Yuan] Cent South Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha, Hunan, Peoples R China.

[Fang, Yuan] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.

[Wang, Xin] Cent South Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.

[Xiong, Wu] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.

[Zhang, Xi] Hunan Univ Chinese Med, Hunan Brain Hosp, Clin Med Sch, Changsha, Hunan, Peoples R China.

通讯机构：

[Haibo Li; Jianda Zhou] D

Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China<&wdkj&>Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

语种：

英文

关键词：

Computational biology;MicroRNAs;Skin aging;Ultraviolet rays

期刊：

Anais Brasileiros de Dermatologia

ISSN：

0365-0596

年：

2022

卷：

期：

页码：

458-466

DOI：

10.1016/j.abd.2022.01.003

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Background: UVB irradiation can cause acute damage such as sunburn, or photoaging and melanoma, all of which are major health threats. Objective: This study was designed to investigate the mechanism of skin photoaging induced by UVB radiation in mice through the analysis of the differential expression of miRNAs. Methods: A UVB irradiation photoaging model was constructed. HE and Masson special stains were used to examine the modifications in the epidermis and dermis of mice. The miRNA expression profiles of the mouse skin model exposed to UVB radiation and the normal skin of mice were analyzed...

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UVB irradiation differential regulate miRNAs expression in skin photoaging

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