期刊论文

中文

中国中医骨伤科杂志

1005-0205

2012

20

4

8-10

本校为第一机构

目的:探讨复灌Ⅰ号注射液对大鼠肢体缺血-再灌注损伤骨骼肌钙调蛋白表达的影响.方法:54只SD大鼠随机分为3大组,分别为对照组(control组)、缺血-再灌注组(IR组)和复灌Ⅰ号药物干预组(Ⅰ-IR组).对照组所有大鼠不阻断血流；IR组和Ⅰ-IR组复制右后肢缺血-再灌注模型.对照组动物处死前不给药物,缺血-再灌注组于造成缺血前12h、造成缺血时和再灌注时于腹腔内各注射生理盐水1mL;复灌Ⅰ号药物干预组于造成缺血前12h、缺血时和再灌注时腹腔各注射复灌Ⅰ号注射液1mL.各组动物于再灌注0h、2h、4h、8h等时间点在右后肢相应区域切取约100mg腓肠肌,冰盐水快速洗去血液,滤纸吸干水份,剪碎制成组织匀浆,用于兰尼...

Objective：To study the influence of Fuguan InjectionⅠ on calmodulin expression in skeletal muscle of ischemic-reperfusion injury rats.Methods： Fifty-four rats were divided into 3 groups at random： control group,ischemic-reperfusion group（IR group） and Fuguan injection Ⅰ intervention group（Ⅰ-IR group）.The rats in control group did not undergo blockade of blood flow in posterior limbs.The ischemic reperfusion models of rats in rats＇ posterior limbs in IR group and Ⅰ-IR group were established by the method suggested by Zhang Lianyuan.N...