期刊论文

中文

中国中医骨伤科杂志

1005-0205

2013

21

6

1-4

国家教育部新教师基金（20094323120005）等项目资助；

本校为第一机构

目的:通过对去势大鼠整合素表达水平的观察,揭示金刚健骨片治疗骨质疏松症的作用机理.方法:将50只10月龄Wistar雌性大鼠随机分为5组:阿仑磷酸钠组、金刚健骨片组、骨松宝颗粒组、模型组、假手术组.治疗组及模型组行卵巢摘除术,假手术组切除相同重量的肠系膜.统一饲养13周造模成功后,治疗组分别以相应药物连续给药13周；模型组及假手术组以生理盐水替代.治疗结束后处死动物取出骨组织,进行骨密度测定,并利用免疫组化法测定整合素αⅤ β6表达水平.结果:治疗组的骨密度、整合素αⅤβ6均较模型组有明显提高,差异有统计学意义(P＜0.05)；金刚健骨片组与阿仑膦酸钠组对提高大鼠骨密度均高于骨松宝组...

Objective：To investigate the regulatory effect of Jingang Jiangu pill （JGJG） on integrin in ovariectomized osteo- porosis rats. Methods：All 50 ovariectomized female rats, 10 months old, were randomly divided into 5 groups： alunlinsu- anna group, Jingang Jiangu pill group, Gu Songbao granule group, model group, and the sham group. After ovariecto- mized, the rats were raised in the same environment for 13 weeks. Then treatment group were treated with different medi- cine for another 13 weeks, the model group and sham group were treated with...