期刊论文

中文

中国中医骨伤科杂志

1005-0205

2024

32

01

7-12

10.20085/j.cnki.issn1005-0205.240102

81574005:国家自然科学基金 kq2004057:长沙市科技计划项目 202128:湖南省中医药研究院院级重点课题

本校为第一机构

目的:探讨肾脏尿酸盐转运子1(Urate Transporter 1,URAT1)、三磷酸腺苷结合盒转运蛋白G2(ATP-binding Cassette Superfamily G Member 2,ABCG2)、葡萄糖转运蛋白 9(Glucose Transporter 9,GLUT9)等尿酸转运蛋白在蠲痹历节清方降低血尿酸(Serum Uric Acid,SUA)中的机制.方法:将雄性SD大鼠随机分为空白组、模型组、苯溴马隆组(5 mg/kg)及蠲痹历节清方低、中、高剂量组(11,22,44 g/kg).除空白组外,其余各组均建立高尿酸血症模型;苯溴马隆组和蠲痹历节清方组分别予相应浓度混悬液进行灌胃干预.最后收集大鼠腹主动脉血和双肾组织,采用全自动生化仪检测各组大鼠腹主动脉中血尿酸含量,采用实时荧光定量...

Objective:To study the mechanism of Juanbili-jieqing recipe in reducing serum uric acid(SUA)from the uric acid transporters such as renal URAT1(urate trans-porter 1),ABCG2(ATP-binding cassette superfamily G member 2)and GLUT9(glucose transporter 9).Methods:SD male rats were randomly divided into control group,mod-el group,benzbromarone group(5 mg/kg),low,medium and high dose groups(11,22,44 g/kg)of Juanbilijieqing recipe.Except for the blank group,hyperuricemia models were established in all other groups.Benzbromarone group and Juanbili-jieqing...