This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2019A1515110047), Medical Scientific Research Foundation of Guangdong Province of China (A2019155), Sanming Project of Medicine in Shenzhen (SZSM201612079), and Hunan Provincial Innovation Foundation for Post-graduate (CX20190159). The funding body did not have any part in the design of the study; collection, analysis, and interpretation of data; and in writing the manuscript.