Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Dafeng;Yang, Zhousheng;Chen, Lei;Kuang, Dabin;Zou, Yang;...

通讯作者：

Tan, Shenglan

作者机构：

[Yan, Miao; Tan, Shenglan; Yang, Dafeng; Chen, Lei] Cent South Univ, Inst Clin Pharm, Xiangya Hosp 2, Dept Pharm, 139 Renmin Rd Cent, Changsha 410011, Hunan, Peoples R China.

[Yang, Dafeng; Zhou, Yangzhao] Cent South Univ, Dept Cardiovasc Surg, Xiangya Hosp 2, Changsha, Peoples R China.

[Zou, Yang; Yang, Zhousheng] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Pharm, Nanning, Peoples R China.

[Kuang, Dabin] Hunan Normal Univ, Dept Pharm, Affiliated Changsha Hosp, Changsha, Peoples R China.

[Li, Jie] Guangzhou Med Univ, Dept Geriatr, Natl Key Clin Specialty, Guangzhou Peoples Hosp 1, Guangzhou, Peoples R China.

通讯机构：

[Tan, Shenglan] C

Cent South Univ, Inst Clin Pharm, Xiangya Hosp 2, Dept Pharm, 139 Renmin Rd Cent, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

atherosclerosis;dihydromyricetin;endothelial cell;microRNA;nitric oxide

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2020

卷：

期：

页码：

5911-5925

DOI：

10.1111/jcmm.15278

基金类别：

Hunan Province Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ40430, 2018JJ3731, 2019JJ50680]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81703818, 81400331, 81803767]; The Science Foundation of Guangzhou First People's Hospital [Q2019005]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Natural products were extracted from traditional Chinese herbal emerging as potential therapeutic drugs for treating cardiovascular diseases. This study examines the role and underlying mechanism of dihydromyricetin (DMY), a natural compound extracted from Ampelopsis grossedentata, in atherosclerosis. DMY treatment significantly inhibits atherosclerotic lesion formation, proinflammatory gene expression and the influx of lesional macrophages and CD4-positive T cells in the vessel wall and hepatic inflammation, whereas increases nitric oxide (NO)...

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Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice

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