期刊论文

Hu, Zhixi;Li, L

英文

Frontiers in Microbiology

1664-302X

2025

16

1509548

10.3389/fmicb.2025.1509548

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation of China (nos. 82305092, 82274412, and 82274411), National Natural Science Foundation of Hunan Province (no. 2023JJ30453), Science and Technology Innovation Program of Hunan Province (2024RC3199), and Hunan University of Chinese Medicine Scientific Research Fund Outstanding Youth Project (Z2023XJYQ03).

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OBJECTIVE: To investigate the relationship between heart failure (HF) and gut microbiota-mediated energy metabolism, and to explore the role of Shenfu Injection in this process. MATERIALS AND METHODS: In this study, Adriamycin-induced chronic heart failure (CHF) rat model was used and randomly divided into the blank control group (Normal, n = 9), HF control group (Model, n = 12), Shenfu Injection treatment group (SFI, n = 9), and positive drug control group (TMZ, n = 9). The changes in gut microbiota structure were analyzed by 16S rRNA ...