The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma

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成果类型：

期刊论文

作者：

Liu, Jin;Zhu, Mingyi;Feng, Yun;Tang, Qianli;Xu, Meng

通讯作者：

Tang, QL

作者机构：

[Liu, Jin] Hunan Univ Chinese Med, Postdoctoral Stn Combinat Chinese Tradit & Wester, Changsha 410208, Hunan, Peoples R China.

[Liu, Jin] Youjiang Med Univ Nationalities, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China.

[Zhu, Mingyi] Youjiang Med Univ Nationalities, Dept Pathophysiol, Baise 533000, Guangxi, Peoples R China.

[Feng, Yun] Youjiang Med Univ Nationalities, Dept Neurol, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China.

[Tang, Qianli] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Tang, QL ] H

Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

Youjiang Med Univ Nationalities, Baise 533000, Guangxi, Peoples R China.

语种：

英文

关键词：

LRP;Multidrug resistance;NF-κB;P-gp;PI3K/Akt;nasopharynx carcinoma

期刊：

BIOSCIENCE REPORTS

ISSN：

0144-8463

年：

2020

卷：

期：

页码：

BSR20190239.

DOI：

10.1042/BSR20190239

基金类别：

We thank the financial reports of The Self-funded Research Projects of National Health and Family Planning Commission of Guangxi [grant number Z20170226], Basic Ability Improvement Project for young and middle-aged teachers of universities in Guangxi [grant number 2018ky0451] and Special Funding for Guangxi Special Experts [grant number GRCT[2019]13#].

机构署名：

本校为第一且通讯机构

摘要：

Abstract Aim: To investigate the relationship between PI3K/Akt/NF-κB cellular signal pathway and the expression of P-gp and LRP in multidrug resistance (MDR) cell of nasopharyngeal carcinoma. Method: The PI3K, p-Akt and NF-κB/p65 as the activity of PI3K/Akt/NF-κB were detected by Western blot. The expressions of LRP and P-gp were detected by Western blot and real-time PCR. Result: The RIs of CNE/DDP group to DDP, 5-Fu, VCR, ADR and PTX were 35.04, 18.14, 24.13, 12.00 and 10.18, respectively. The RIs of LY-294002 group were 11.77, 5.83, 3....

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The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma

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