期刊论文

The Experimental Study on the Effects of Conggan Zhixin Prescription（CGZXP） in Rat Myocardial An- giogenesis Factor Ang-1 ,Ang-2 Expression

中文

中国中医急症

1004-745X

2013

22

11

1830-1833

湖南省教育厅科研项目（07A051）；

本校为第一机构

目的 观察从肝治心组方(CGZXP)对冠心病心肌缺血大鼠局部缺血心肌血管生成素-1(Ang-1)、血管生成素-2(Ang-2)蛋白表达,以及对缺血血管新生作用的影响.方法 SD大鼠按随机方法分成假手术组、模型组、麝香保心丸组和从肝治心方组4组.采用冠脉结扎法诱导急性心肌梗死模型,造模24h后给药,每日1次.于造模14d后处死大鼠,取出心脏,肉眼观察心肌情况,应用免疫组织化学法进行缺血心肌Ang-1、Ang-2蛋白表达的检测.结果 从肝治心方组对改善大鼠活动、对外界反应、精神、食欲、皮毛质感等均优于其他各组;免疫组化结果提示从肝治心方组和麝香保心丸组的心肌细胞Ang-1的表达高于模型组,Ang-2的表达低于模型组(P...

Objective： To observe the effects of Conggan Zhixin Prescription（CGZXP） on myocardial ischemic of Ang-1 and Ang-2 protein expression and to promote the role of ischemic angiogenesis on myocardial ischemic in rats. Methods： According to completely random method SD rats were divided into 4 groups： Sham operation group,the model group,the Shexiangbaoxin pill group and Conggan Zhixin Prescription group. Acute myocardial infarction was induced by coronary artery ligation model. Acute myocardial infarction animal models were induced by ligating ...