期刊论文

The Effect of Yixin Tai on Calcineurin Signal Pathway of Rats with Chronic Heart Failure

中文

中国中医急症

1004-745X

2013

22

1

17-19

10.3969/j.issn.1004-745X.2013.01.008

基金项目：湖南省自然科学基金项目（10JJ2026）

本校为第一机构

目的 探讨益心泰对慢性心力衰竭大鼠心肌重构钙调神经磷酸酶信号通道的影响.方法 50只健康Wistar雄性大鼠分为模型组、益心泰高剂量组、益心泰中剂量组、益心泰低剂量组和培哚普利组,每组10只；另设没有进行造模处理的空白对照组10只.实验动物每日上午按下列剂量灌胃给药1次:正常组不进行药物干预；模空组灌服同等容积的生理盐水;益心泰丸高剂量组灌服10.5 g/(kg·d)；益心泰丸中剂量组灌服5.5 g/(kg·d)；益心泰丸低剂量组灌服2.5 g/(kg·d)；培哚普利组灌服4.5 g/(kg·d),均每日1次.用药8周后观察心肌组织心肌组织钙调神经磷酸酶(CaN)、CaN、活化T细胞核因子(NFAT3)磷酸化及蛋白的相对表达.结...

Objective：To observe the effect of Yixin Tai on calcineurin signal pathway of rats with chronic heart failure. Methods：50 healthy male Wistar rats were divided averagely into six group：model group,Yixin Tai high dose group,Yixin Tai middle dose group, Yixin Tai low dose group,perindopril group and normal control group with no mold processing. Every morning experimental animal were given drug as following method： normal group were given no drug,Yixin Tai high dose group 10.5g/（kg.d）,Yixin Tai middle dose group 5.5g/（kg.d）,Yixin Tai low d...