期刊论文

Therapeutic Effect of Liuwei Dihuang Decoction on IgA Nephropathy Rats PENG

中文

中国中医急症

1004-745X

2015

24

12

2093-2096,2129

10.3969/j.issn.1004-745X.2015.12.008

湖南省科技厅项目基金（No.2013SK3099）；

本校为第一机构

目的 观察六味地黄丸方对IgA肾病大鼠的治疗作用.方法 SD大鼠40只随机分为正常对照组、模型组、雷公藤多苷片组、六味地黄丸方组,各10只.除正常组外均采用运用牛血清白蛋白+脂多糖+四氯化碳方法建立实验性IgAN模型.造模成功后连续灌胃4周,正常对照组及模型组均采用蒸馏水灌胃;雷公藤多苷片组以6 mg/(kg·d)溶于等体积0.9％氯化钠溶液灌胃;六味地黄汤组以大鼠及人体质量与相应体表面积比值计算给药量.分别在每周末检测尿蛋白定量及尿红细胞计数,第4周末处死各组大鼠,进行肝肾功能检测,IgA免疫荧光检测,肾脏组织石蜡切片进行HE、PAS染色,光镜及电镜下观察病理改变及半定量评估.结果 六味地黄丸方组...

Objective： To examine the therapeutic effect of Liuwei Dihuang Decoction on IgA Nephropathy Rats. Methods： Forty SD rats were equally randomized into 4 groups： the eonrol group, the model group, tripterygium glycosides group, Liuwei Dihuang decoction group. Except the control group, IgAN rat model was established with bovine serum albumin （BSA）, lipopolysaccharide （LPS） and carbon tetrachloride （CC14）. After 4 weeks of contin- uous perfusion, the control group and the model group were perfused with distilled water, Tripterygium glycosi...