期刊论文

中文

中国中医急症

1004-745X

2016

25

3

393-396

10.3969/j.issn.1004-745X.2016.03.006

湖南省自然科学基金（14JJ6038） 湖南省科技厅课题（2014sk3037）

本校为第一机构

目的观察活血荣络片对阿尔茨海默病（AD）小鼠脑组织乙酰胆碱酯酶（Ach E）和乙酰胆碱转移酶（Ch AT）表达的影响。方法将50只APP/PS1双转基因AD模型小鼠随机分为模型组、低剂量活血荣络片组、中剂量活血荣络片组、高剂量活血荣络片组、多奈哌齐组,每组10只。同期将同月龄的10只KM小鼠作为正常组。每天灌胃1次,连续治疗2个月。治疗结束后,取各组小鼠脑组织,采用Western Blot检测Ach E和Ch AT蛋白含量。结果与正常组相比,AD模型组小鼠脑组织Ach E蛋白表达提高、Ch AT蛋白表达降低（P

Objective： To investigate the effect of Huoxue Rongluo Tablets on the expression of acetylcholinesterase（Ach E） and acetylcholine transferase（Ch AT） in brain tissue of mice with Alzheimer′ s disease（AD）. Methods： 50 APP/PS1 transgenic AD model mice were randomly divided into five groups,with 10 rats in each. 10 KM mice with the same age were chosen as the normal group. The stomach was filled once a day,and continuous treatment lasted for 2 months. After treatment,the brain tissues of mice were taken to detect the content of Ach E and C...