期刊论文

Effects of Yiqi Huoxue Decoction on the Expression of PDGF in Rats with Acute Myocardial Ischemia

中文

中国中医急症

1004-745X

2017

26

9

1529-1532

10.3969/j.issn.1004-745X.2017.09.008

2015SK20161:湖南省科技厅项目 2015SK2016:湖南省科技厅项目

本校为第一机构

目的 观察益气活血组方对于急性缺血缺氧的心肌组织血管新生的作用及其机制.方法 采用结扎健康的SD雄性大鼠左冠脉的前降支,建立急性缺血缺氧的心肌梗死的模型,造模成功后的45只大鼠随机分为模型组、芪参益气滴丸组、益气活血方组,假手术组15只大鼠模型仅穿线不结扎,各组在根据处死时间随机分为3d、7d、14d 3个时相组.观察不同组别不同时相HE染色情况及血小板衍生生长因子(PDGF)蛋白的表达情况.结果 与假手术组,模型组相比,益气活血组方HE染色可见较多增生的毛细血管;PDGF蛋白表达在芪参益气滴丸组和益气活血组方表达较高(P

Objective： To investigate the effect and mechanism of Yiqi Huoxue Decoction on angiogenesis in myocardial tissue of rats with acute ischemia and hypoxia. Methods： A model of acute hypoxic ischemic myocardial infarction was established by ligating the anterior descending branch of the left coronary artery in healthy SD male rats. After the success of the model,45 rats were randomly divided into the model group,Qishen Yiqi Decoction group and Yiqi Huoxue Decoction group. In the sham operation group,15 rats only wore thread without ligation. Acc...