期刊论文

Discussion on the Influence of Tablet Qingrejieduhuazhuo on tPA and PAI-1 in Rats with IETM from the Relation between Micro-ecology and Cardiovascular Damage

中文

中国中医急症

1004-745X

2017

26

1

46-49

10.3969/j.issn.1004-745X.2017.01.013

湖南省教育厅重点项目资助（12A101） 湖南中医药大学中医药临床基础重点学科资助

本校为第一机构

目的 从微生态与心血管损伤关系探讨清热解毒化浊片对心与动脉的影响.方法 70只SD大鼠随机分为正常组和造模组,造模组采用高脂、酒精复合因素干预12周建立肠源性内毒素血症(IETM)大鼠模型.造模成功后,按随机数列表法分为模型组、清热解毒化浊片组.经过4周治疗后采血检测内毒素(LPS)水平,观察心肌及主动脉组织病理变化,免疫组化法测定组织型纤溶酶原激活物(tPA)、纤溶酶原激活物抑制剂(PAI)在心肌及主动脉组织中的表达.结果 1)与正常组比较,模型组血浆LPS明显升高(P＜0.01);心肌及主动脉组织PAI-1表达明显升高(P＜0.01)、tPA明显减低(P＜0.01);2)与模型组比较,清热解毒化浊片组,血浆LPS明显降低(...

Objective： To discuss the influence of Tablet Qingrejieduhuazhuo on heart and arteries from the re- lation between micro-ecology and cardiovascular damage. Methods： 70 SD rats were randomly divided into the normal group and the model group. Intestinal endotoxemia （IETM） rat models were established by intervention with high fat and alcohol composite factors for 12 weeks in the model group. The successful rat models were randomly divided into the model group and the Tablet Qingrefieduhuazhuo group. After 4 weeks of treatment,the endotoxin lev...