期刊论文

Effects of Goushao Jiangya Granule on Angiotensin lI and Renal Artery Calcium Sening Receptor in Spontaneously Hypertensive Rats

中文

中国中医急症

1004-745X

2018

27

5

793-796

10.3969/j.issn.1004-745X.2018.05.011

湖南省自然科学基金课题（14JJ7087）；

本校为第一机构

目的 研究钩芍降压颗粒对自发性高血压大鼠血管紧张素Ⅱ及肾动脉钙敏感受体的影响,探讨钩芍降压颗粒可能的作用机制.方法 取雄性自发性高血压大鼠30只,随机分为模型对照组、阳性对照组及试验组,每组10只,另雄性Wistar大鼠10只作为空白对照组.阳性对照组予厄贝沙坦,试验组钩芍降压颗粒、模型对照组与空白对照组予等量蒸馏水.每日1次,连续4周.每周检测血压、酶联免疫吸附法测定血清血管紧张素Ⅱ含量、免疫组化法检测钙敏感受体表达.结果 与阳性对照药比较,钩芍降压颗粒起效慢、作用轻微.血清血管紧张素Ⅱ含量,模型对照组、阳性对照组与空白对照组比较,差异有显著统计学意义(P＜0.01);试验组与空白...

Objective:To research the influence of Goushao Jiangya Granule on Angiotensin Ⅱ and renal artery calcium sensing receptor in spontaneously hypertensive rats.Methods:30 SHR were randomly divided into the model control,the positive control group and the experimental group,another 10 Wistar rats as the blank control group.The positive control group was gave Irbesartan Tablets.The experimental group was gave Goushao Jiangya Granule.The model control group and the blank control group were given equal distilled warter.It lasted for 4 weeks,once per ...