期刊论文

中文

中国中医急症

1004-745X

2019

28

9

1567-1570

10.3969/j.issn.1004-745X.2019.09.017

湖南省科技厅重点研发项目(2016SK2051) 抗肿瘤中药创制技术湖南省工程研究中心专项基金.

本校为第一机构

目的 探讨蟾龙镇痛膏镇痛对骨癌痛大鼠的镇痛作用及可能机制.方法 将50只雌性SD大鼠随机分为空白组、模型组、蟾龙镇痛膏常规剂量组、蟾龙镇痛膏高剂量组和扶他林组,每组10只.骨癌痛模型造模方式采用右侧后肢胫骨注射Walker256乳腺癌肿瘤细胞悬液,空白组正常饲养,在造模后14d开始外敷相应药物,每日1次,连续21d.观察大鼠热痛觉缩足反射潜伏期(PWL)、机械痛觉缩足反射阈值(PWT)变化情况,检测大鼠L4～L6脊髓磷酸化38蛋白(p-p38)、磷酸化细胞外信号调节激酶1/2(p-ERK1/2)的表达情况.结果 模型组大鼠痛阈较空白组、蟾龙镇痛膏常规剂量组、蟾龙镇痛膏高剂量组和扶他林组明显降低(P＜0.05);模型组脊髓p...

Objective:To explore the analgesic effect and possible mechanism of Chanlong Zhentong Plaster (CZP)on bone cancer pain in rat model.Methods:50 female SD rats were randomly divided into the control group,the model group,CZP normal-dose group,CZP high-dose group and Voltaren group,10 rats in each.Expect the control group,the others were injected with Walker256 breast cancer cell suspension in the right hind limb to establish bone cancer pain model.The drug began to apply on the 14th day after surgery,once a day for 21 days. The changes of PWL and PWT were observed,and the expression of p-p38 and...