期刊论文

Research on Mechanism of Traditional Chinese Medicine on"Hemiplegia"of Cerebral Infarction Based on Network Pharmacology

中文

中国中医急症

1004-745X

2020

29

8

1348-1351

10.3969/j.issn.1004-745X.2020.08.010

81573941:国家自然科学基金 81774033:国家自然科学基金 102210001019132:湖南中医药大学校级大学生研究性学习和创新性试验计划课题项目 :湖南中医药大学中医学国内一流建设学科

本校为第一机构

目的 运用网络药理学方法,结合中医药临床或实验研究,探讨中医药治疗脑梗死后半身不遂的作用机制.方法 借助人类基因数据库(GeneCards)、HPO数据库筛选脑梗死与半身不遂疾病靶点,运用STRING11.0数据库、Cytoscape3.6.1软件对靶点进行PPI网络构建,运用DAVID 6.8数据库对靶点进行基因本体(G0)富集、KEGG通路注释分析.结果 对脑梗死与半身不遂现有的靶标进行分析后得到39个共有靶标,PPI网络图显示前10个联系最多的靶点是TP53、TNF、IL10、MMP9、SNCA、TGFB1、PTEN、MTOR、SOD1、ACTA2.GO富集和KEGG注释分析结果显示,中医药治疗脑梗死后半身不遂与抗氧化、抑制脑组织细胞凋亡、抑制炎症反应、促进血...

Objective:To investigate the mechanism of traditional Chinese medicine on hemiplegia of cerebral infarction based on network pharmacology and clinical or experimental study of TCM.Methods:The targets of cerebral infarction and hemiplegia were screened by GeneCards database and HPO database.STRING 11.0 database and Cytoscape 3.6.1 software were used to construct PPI network of targets.DAVID 6.8 database was used for GO enrichment and KEGG pathway annotation analysis.Results:39 common targets were obtained after analyzing targets of cerebral infarction and hemiplegia.PPI network map showed that ...