期刊论文

Effects of Xintongtai on Blood Lipid,Fibrinolytic System and Myocardium in Rats with Coronary Heart Disease

中文

中国中医急症

1004-745X

2020

29

8

1339-1343

10.3969/j.issn.1004-745X.2020.08.008

国家自然科学基金青年基金项目(81804077) 湖南省自然科学基金青年基金项目(2019JJ50468) 湖南中医药大学中医学国内一流建设学科。

本校为第一机构

目的观察心痛泰颗粒对冠心病大鼠血清中血脂、纤溶系统的影响及心肌组织形态学改变,并探讨心痛泰对冠心病大鼠的治疗作用及机制。方法将95只4周龄SD大鼠随机抽取17只作为空白组。其余78只SD大鼠进行造模（灌胃高脂饲料12周）,造模后随机抽取75只分为模型组、心痛泰高剂量组、心痛泰中剂量组、心痛泰低剂量组、卡托普利组,每组各15只。第13周开始,各组分别予相应药物灌胃治疗,正常组和模型组以等体积的蒸馏水灌胃,每日1次,连续灌胃4周。于实验后,采用腹主动脉取血,化学发光法检测甘油三酯（TAG）、胆固醇（TC）水平。使用ELISA法检测血浆纤溶酶原激活剂（t-PA）和纤溶酶原激活物抑制物（PAI-1）水...

Objective:To observe the effect of Xintongtai on serum lipids,fibrinolytic system and myocardial histomorphology in rats with coronary heart disease,and to explore its therapeutic effect and mechanism.Methods:17 out of 954-week-old SD rats were randomly selected as the blank control group,and the other 78 ones were modeled.75 rats were randomly divided into the model group,high-dose group,middle-dose group,low-dose group and Captopril group according to the weight stratification,15 rats in each.At the beginning of the 14 th week,each group was treated with corresponding drugs.The normal group ...