Panax notoginseng Alleviates Colitis via the Regulation of Gut Microbiota

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成果类型：

期刊论文

作者：

Wang, Li;Shao, Li;Chen, Man-Yun;Wang, Lin;Yang, Pu;...

通讯作者：

Wei-Hua Huang

作者机构：

[Huang, Wei-Hua; Wang, Li; Zhang, Wei; Wang, Lin; Chen, Man-Yun] Cent South Univ, Dept Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Huang, Wei-Hua; Wang, Li; Zhang, Wei; Wang, Lin; Chen, Man-Yun] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China.

[Huang, Wei-Hua; Wang, Li; Zhang, Wei; Wang, Lin; Chen, Man-Yun] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Xiangya Rd 110, Changsha 410008, Hunan, Peoples R China.

[Shao, Li] Cent South Univ, Xiangya Hosp, Dept Gen Surg, Xiangya Rd 110, Changsha 410008, Hunan, Peoples R China.

[Yang, Pu; Tan, Feng-Bo] Hunan Univ Chinese Med, Sch Pharm, Dept Pharmacognosy, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Wei-Hua Huang] D

Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P. R. China<&wdkj&>Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics Xiangya Hospital, Central South University, Changsha, Hunan 410078, P. R. China<&wdkj&>National Clinical Research Center for Geriatric Disorders, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410128, P. R. China

语种：

英文

关键词：

Akkermansia;Bacteroides;Colitis;Ginsenoside;Panax notoginseng;Rb1;Rd;Rg1;Saponins

期刊：

American Journal of Chinese Medicine

ISSN：

0192-415X

年：

2022

卷：

期：

页码：

107-127

DOI：

10.1142/S0192415X23500076

基金类别：

National Natural Scientific Foundation of China [82074000, 81903784]; Hunan Provincial Natural Science Foundation of China [2020JJ4878]; Scientific Research Project of Department of Education of Hunan Province [20K136]; Traditional Chinese medicine research project of Hunan Province [2021034]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Gut microbiota are significantly associated with the occurrence and development of inflammatory bowel disease (IBD). Panax notoginseng saponins (PNS) could be used for colitis and to modulate gut microbiota. However, the mechanism behind the effects of PNS on anti-colitis that are pertinent to gut microbiota is largely unknown. This study aimed to evaluate the anti-colitis effects of PNS and explore the involved mechanism as it is related to gut microbiota. Results showed that PNS significantly alleviated dextran sulfate sodium (DSS)-induced colitis. Meanwhile, after PNS treatment, the tight j...

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Panax notoginseng Alleviates Colitis via the Regulation of Gut Microbiota

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