A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xia, Yuchen;Wang, Guihua;Jiang, Manli;Liu, Xueting;Zhao, Yan;...

通讯作者：

Guihua Wang<&wdkj&>Jinyue Hu

作者机构：

[Xia, Yuchen] Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China.

[Xia, Yuchen; Wang, Guihua] Univ South China, Changsha Cent Hosp, Dept Oncol, Changsha, Hunan, Peoples R China.

[Hu, Jinyue; Jiang, Binyuan; Jiang, Manli; Liu, Xueting] Univ South China, Changsha Cent Hosp, Med Res Ctr, Changsha 410004, Hunan, Peoples R China.

[Zhu, Demao; Zhao, Yan] Univ South China, Changsha Cent Hosp, Dept Pathol, Changsha, Hunan, Peoples R China.

[Song, Yinghui] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Hepatobiliary Surg, Changsha, Hunan, Peoples R China.

通讯机构：

[Guihua Wang] D

[Jinyue Hu] M

Department of Oncology, Changsha Central Hospital, University of South China, Changsha, Hunan, People��s Republic of China<&wdkj&>Medical Research Center, Changsha Central Hospital, University of South China, Changsha, Hunan, People��s Republic of China

语种：

英文

关键词：

Stattic;glutathione reductase;cell death;cervical cancer;reactive oxygen species;tumor growth

期刊：

OncoTargets and Therapy

ISSN：

1178-6930

年：

2021

卷：

页码：

4047-4060

DOI：

10.2147/OTT.S313507

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172042]

机构署名：

本校为第一机构

院系归属：

研究生院

摘要：

Introduction: Glutathione reductase (GSR) provides reduced glutathione (GSH) to main-tain redox homeostasis. Inhibition of GSR disrupts this balance, resulting in cell damage, which benefits cancer therapy. However, the effect of GSR inhibition on the tumorigenicity of human cervical cancer is not fully understood. Materials and Methods: Tissue microarray analysis was employed to determine GSR expression in cervical cancer tissues by immunohistochemical staining. Cell death was measured with PI/FITC-annexin V staining. mRNA levels were measured via quantitative RT-PCR. Protein expression was m...

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A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway

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