Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus

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成果类型：

期刊论文

作者：

Gu, Hong-Feng;Li, Na;Tang, Ya-Ling;Yan, Can-Qun;Shi, Zhe;...

通讯作者：

OuYang, Xin-Ping;Liao, Duan-Fang

作者机构：

[Gu, Hong-Feng; Li, Na; Tang, Ya-Ling; OuYang, Xin-Ping] Univ South China, Dept Physiol, Hengyang, Peoples R China

[Gu, Hong-Feng; Li, Na; Tang, Ya-Ling; OuYang, Xin-Ping] Univ South China, Inst Neurosci, Hengyang, Peoples R China

[Yan, Can-Qun; Yi, Si-Ni; Zhou, Hao-Ling] Univ South China, Affiliated Hosp 2, Dept Endocrine, Hengyang, Peoples R China

[Shi, Zhe; Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China

通讯机构：

[OuYang, Xin-Ping] U

[Liao, Duan-Fang] H

Univ South China, Dept Physiol, Hengyang, Peoples R China. Univ South China, Inst Neurosci, Hengyang, Peoples R China. Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

autophagy;cognitive function;diabetes mellitus;hippocampus;mammalian target of rapamycin complex;nicotinate-curcumin

期刊：

CNS Neuroscience & Therapeutics

ISSN：

1755-5930

年：

2019

卷：

期：

页码：

430-441

DOI：

10.1111/cns.13059

基金类别：

Aid Program for Chinese Medicine of Human Province, China [201524]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2016JJ2112]; Graduate Student Scientific Research Innovation Project of Hunan Province, China [CX2017B548]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670268, 81500349]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

INTRODUCTION: Our previous study has confirmed that a novel curcumin derivate nicotinate-curcumin (NC) can facilitate autophagic flux in THP-1 cells induced by oxidized low-density lipoprotein. AIMS: Given that autophagy plays critical roles in neurodegenerative diseases, the present study was carried out to investigate whether NC can improve cognitive function of rats with diabetes mellitus (DM) via restoring autophagic flux in CA1 hippocampus. RESULTS: Our results showed that NC treatment improved cognitive deficit and attenuated neuronal loss as well as cellular ultrastructure impairment in...

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Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus

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