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Ginsenoside Rb3 reduces ox-LDL-induced injury in human aortic endothelial cells by regulating the miR-513a-5p/ZBTB20 axis

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成果类型:
期刊论文
作者:
Wang, Hua;Liu, Lin;Cai, Huzhi
通讯作者:
Cai, HZ
作者机构:
[Wang, Hua] Hunan Univ Tradit Chinese M, Affiliated Hosp 1, Dept Agcy Off, Changsha, Peoples R China.
[Liu, Lin] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Innovat Expt Ctr, Changsha, Peoples R China.
[Cai, Huzhi] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Sci Res, Changsha, Peoples R China.
通讯机构:
[Cai, HZ ] H
Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Sci Res, Changsha, Peoples R China.
语种:
英文
关键词:
atherosclerosis;oxidized low-density lipoprotein;miR-513a-5p;ZBTB20
期刊:
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
ISSN:
1899-5276
年:
2023
卷:
32
期:
11
页码:
1291-1298
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
摘要:
BACKGROUND: Atherosclerosis (AS) is a common vascular disease, and its main influencing factor is endothelial damage caused by oxidized low-density lipoprotein (ox-LDL). As one of the main active ingredients of ginseng, ginsenoside Rb3 has anti-inflammatory and anti-oxidative effects. However, the role of ginsenoside Rb3 in endothelial injury induced by ox-LDL is not clear. OBJECTIVES: This study aimed to evaluate the effect and potential mechanism of ginsenoside Rb3 action on ox-LDL-treated human aortic endothelial cells (HAECs). MATERIAL AND ...

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