期刊论文

Fangguo Lu

英文

Drug Delivery

1071-7544

2022

29

1

1675-1683

10.1080/10717544.2022.2079768

We would like to thank National Natural Science Foundation [81803964, 82074250], Natural Science Foundation of Hunan Province [2020JJ4465, 2020JJ4063], Key Project of the Department of Education of Hunan Province [21A0237], The first-class cultivation subject of integrated Chinese and Western medicine in Hunan Province [2021ZXYJH14], Research and Innovation Program for postgraduates in Hunan Province [CX20210700], National Innovation and Entrepreneurship Training Program for college students [S201910541002], Xinglin talent cultivation program, Basic medicine construction project of Hunan University of traditional Chinese Medicine (No. 6), and Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine [2019TP1044] for the financial support.

本校为第一机构

Biofilm formation is known to promote drug resistance in methicillin-resistant Staphylococcus aureus (MRSA), which is closely related to persistent infections in hospital settings. In this study, a DNA aptamer specific to penicillin-binding protein 2a (PBP2a) with a dissociation constant (K d) of 82.97 ± 8.86 nM was obtained after 14 cycles of systematic evolution of ligands by exponential enrichment (SELEX). Next, a bifunctional complex containing the aptamer intercalated by berberine into the double-strand region was prepared and adsorbed on...