The Chinese medicine Xin-tong-tai granule protects atherosclerosis by regulating oxidative stress through NOX/ROS/NF-κB signal pathway

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成果类型：

期刊论文

作者：

Wei, Jia-ming;Yuan, Hui;Liu, Cheng-xin;Wang, Zi-yan;Shi, Zhi Min;...

通讯作者：

Shi, ZM;Li, Y

作者机构：

[Shi, Zhi Min; Wei, Jia-ming] Hunan Univ Chinese Med, Sch Chinese Med, Changsha 410208, Peoples R China.

[Wang, Zi-yan; Yuan, Hui; Liu, Cheng-xin] Hunan Univ Chinese Med, Clin Coll Chinese Med 1, Changsha 410208, Peoples R China.

[Wang, Zi-yan; Shi, Zhi Min; Yuan, Hui; Wei, Jia-ming; Liu, Cheng-xin] Hunan Univ Chinese Med, Hunan Key Lab Coll & Univ Intelligent Tradit Chine, Changsha 410208, Peoples R China.

[Li, Y; Li, Ya] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

通讯机构：

[Li, Y ; Shi, ZM ] H

Hunan Univ Chinese Med, Hunan Key Lab Coll & Univ Intelligent Tradit Chine, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

语种：

英文

关键词：

ApoE(-/-) mice;Atherosclerosis;NOX/ROS/NF-κB signal pathway;Vascular smooth muscle cell;Xin-tong-tai

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2023

卷：

165

页码：

115200

DOI：

10.1016/j.biopha.2023.115200

基金类别：

Natural Science Foundation Project in Hunan Province [2021JJ30492]; Key Subject of Sci-entific Research Projects of Traditional Chinese Medicine in Hunan Province [2021029]; Key Subject of Scientific Research Fund of Hunan Provincial Education Department [20A384]; Key Project of First-class Discipline of Traditional Chinese Medicine of Hunan University of Chinese Medicine [2021ZYX14]; Key Discipline Project on Chinese Parmacology of Hunan University of Chinese Medicine [202302]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Background: Xin-tong-tai Granule (XTTG), a traditional Chinese medicine, has been used to treat atherosclerosis (AS), but its mechanism is poorly understood. Intriguingly, oxidative stress has been recognized as vital factors in the treatment of atherosclerosis. Purpose: This study aims to explore the potential mechanism of XTTG for treating AS. Methods: An in-vivo model of AS was established by feeding ApoE-/- mice with a high-fat diet (HFD), and the Human Aortic Vascular Smooth Muscle Cells (HAVSMCs) were induced by oxidized low-density lipoprotein (oxLDL) in vitro. After treatment, the bloo...

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The Chinese medicine Xin-tong-tai granule protects atherosclerosis by regulating oxidative stress through NOX/ROS/NF-κB signal pathway

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