Exosomes Derived from Astragaloside IV-pretreated Endothelial Progenitor Cells (AS-IV-Exos) Alleviated Endothelial Oxidative Stress and Dysfunction Via the miR-210/ Nox2/ROS Pathway.

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成果类型：

期刊论文

作者：

Xiong, Wu;Zhang, Xi;Zou, Xiao-Ling;Peng, Sai;Lei, Hua-Juan;...

作者机构：

[Xiong, Wu] Department of Burns and Plastic Surgery, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China

[Zhang, Xi] Clinical Medical School of Hunan University of Chinese Medicine, Hunan Brain Hospital, Changsha, 410007, China

[Zou, Xiao-Ling] Department of Endocrinology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China

[Peng, Sai; Lei, Hua-Juan] Department of Anesthesiology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China

[Liu, Xiang-Nan] College of Acupuncture & Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, 410208, China

语种：

英文

关键词：

Astragaloside IV;Nox2;endothelial dysfunction.;exosomes;miR-210;oxidative stress

期刊：

CURRENT MOLECULAR MEDICINE

ISSN：

1566-5240

年：

2024

DOI：

10.2174/0115665240262982240109104620

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

BACKGROUND: Chronic hyperglycemia in diabetes induces oxidative stress, leading to damage to the vascular system. In this study, we aimed to evaluate the effects and mechanisms of AS-IV-Exos in alleviating endothelial oxidative stress and dysfunction caused by high glucose (HG). METHODS: Histopathological changes were observed using HE staining, and CD31 expression was assessed through immunohistochemistry (IHC). Cell proliferation was evaluated through CCK8 and EDU assays. The levels of ROS, SOD, and GSH-Px in the skin tissues of each group were measured using ELISA. Cell adhesion, migration,...

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Exosomes Derived from Astragaloside IV-pretreated Endothelial Progenitor Cells (AS-IV-Exos) Alleviated Endothelial Oxidative Stress and Dysfunction Via the miR-210/ Nox2/ROS Pathway.

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