Objective: to establish and validate a new total statistical moment similarity model (TSMSM) for qualitatively and quantitatively evaluating pharmacokinetic behaviors.Methods: By statistical moment theory (SMT) the total statistical moment (TSM) parameters of pharmacokinetic profiles had been elucidated to further diverted into normal distribution probability density function, and thereby to establish the TSMSM for total pharmacokinetic profile evaluations.The validation trial was designed to self-control test of midazolam pharmacokinetic i...
