Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora

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成果类型：

期刊论文

作者：

Tan, Yang;Li, Yuyan;Zhou, Feng;Guo, Jinming;Wang, Tao;...

通讯作者：

Yang, Yantao;Pei, Gang;Lu, Jiandong

作者机构：

[Tan, Yang; Zhou, Feng; Yang, Yantao; Guo, Jinming; Pei, Gang; Wang, Tao; Shi, Yuhe; Yang, YT; Pei, G] Hunan Univ Chinese Med, Pharm Coll, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Lu, Jiandong; Li, Yuyan] Shenzhen Tradit Chinese Med Hosp, 1 Fuhua Rd, Shenzhen 518033, Guangdong, Peoples R China.

[Yang, Yantao; Pei, Gang] Hunan Prov Engn Technol Ctr Standardizat & Funct, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Yang, YT; Pei, G] H

[Lu, Jiandong] S

Hunan Univ Chinese Med, Pharm Coll, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Shenzhen Tradit Chinese Med Hosp, 1 Fuhua Rd, Shenzhen 518033, Guangdong, Peoples R China.

语种：

英文

关键词：

Triterpenoids from yeyachun;Phenolic acids from danshen;Liver fibrosis;Intestinal flora;Metabolites

期刊：

Journal of Pharmacological Sciences

ISSN：

1347-8613

年：

2020

卷：

143

期：

页码：

165-175

DOI：

10.1016/j.jphs.2020.04.007

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81874424]; Administration Research Project of Hunan Traditional Chinese Medicine (China) [201805]; Hunan University of Chinese Medicine First-class Disciple Construction Project of Chinese Material Medica (China)

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

yeyachun and danshen exist as Chinese patent medicine, Xuemai Tong, and are clearly effective at alleviating liver fibrosis (LF). Previous studies have indicated that triterpenoids from yeyachun (EFT), and phenolic acids from danshen (SMP) are effective in the treatment of LF. The regulation of intestinal flora is an effective method for treating LF. The aim of this study was to investigate the effect of a mixture of EFT and SMP on carbon tetrachloride (CCl4) induced LF. Our results showed the mixture significantly decreased liver damage and fibrosis index, and maintained liver tissue composit...

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Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora

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