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STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation

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成果类型:
期刊论文
作者:
Yang, Zhibo;Chen, Zhenping;Wang, Chang;Huang, Pan;Luo, Meijunzi;...
通讯作者:
Chang Wang
作者机构:
[Huang, Pan; Wang, Chang; Zhou, Rong; Yang, Zhibo; Luo, Meijunzi] Hunan Univ Chinese Med, Dept Dermatol, Affiliated Hosp 2, Changsha 410005, Hunan, Peoples R China.
[Chen, Zhenping] Hunan Univ Chinese Med, Clin Tradit Chinese Med Coll 2, Changsha 410005, Hunan, Peoples R China.
通讯机构:
[Chang Wang] D
Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410005, China
语种:
英文
关键词:
Psoriasis;SH3PXD2A-AS1;miR-125b;STAT3;Positive feedback loop
期刊:
Cytokine+
ISSN:
1043-4666
年:
2021
卷:
144
期:
2
页码:
155535
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774326]; Science and technology innovation leading plan of high-tech industry of Hunan Province [2020SK2023]
机构署名:
本校为第一机构
院系归属:
第二中医临床医学院
摘要:
Psoriasis is a chronic immune-mediated inflammatory dermatosis. STAT3 has been considered a critical regulator of psoriasis pathogenesis due to its role in inflammation and immune responses. Furthermore, alongside noncoding RNAs, including long non-coding RNAs (lncRNAs) and miRNAs, STAT3 also plays a critical role in psoriasis pathogenesis. Two sets of online microarray profiles (GSE50790 and GSE13355) were subsequently downloaded and analyzed to search for lncRNAs upregulated in psoriasis lesion tissues. The expression of lncRNA SH3PXD2A-AS1 could be remarkably upregulated in psoriasis specim...

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