Objective To look for reliable peripheral blood biomarkers for early diagnosis, treatment, mecha-nism of cancerization and evaluation of nasopharyngeal carcinoma (NPC) from familial nasopharyngeal carcinoma. Methods The proteins of peripheral blood mononuclear cells (PBMC) in nasopharyngeal carcinoma (NPC) from famil-ial nasopharyngeal carcinoma, health members of familial nasopharyngeal carcinoma or healthy adults groups were sepa-rated by two-dimensional gel electrophoresis (2DGE), respectively. Then gels were stained by blue silver, scanned by Im-ageScanner and analyzed with PDQuest softwar...