Microneedle system carrying Momordin Ic-loaded ROS-responsive hydrogel ameliorates psoriasis via targeted anti-inflammatory and reactive oxygen species (ROS)-scavenging mechanisms

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成果类型：

期刊论文

作者：

Wang, Chang;Zhou, Lingyue;Han, Zhouxin;He, Lingzhi;Yuan, Jiao;...

通讯作者：

Wang, C

作者机构：

[Han, Zhouxin; Yuan, Jiao; Wang, C; Wang, Shiyu; Wang, Chang; Zhang, Jinqing; He, Lingzhi; Zhu, Qin] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project Ch, Changsha 410005, Peoples R China.

[Zhou, Lingyue] Hunan Univ Chinese Med, Inst Innovat & Appl Res, 300 Bachelor Rd, Changsha 410208, Peoples R China.

通讯机构：

[Wang, C ] H

Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Domest First Class Discipline Construct Project Ch, Changsha 410005, Peoples R China.

语种：

英文

关键词：

Anti-inflammatory;Microneedle;Momordin Ic;Oxidative stress;Psoriasis;ROS-responsive hydrogel

期刊：

International Journal of Pharmaceutics

ISSN：

0378-5173

年：

2025

卷：

676

页码：

125530

DOI：

10.1016/j.ijpharm.2025.125530

基金类别：

CRediT authorship contribution statement Chang Wang: Writing – review & editing, Writing – original draft, Project administration, Methodology, Investigation, acquisition, Formal analysis, Data curation, Conceptualization. Lingyue Zhou: Writing – original draft, Project administration, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Zhouxin Han: Software, Methodology, Investigation, Formal analysis, Data curation. Lingzhi He: Supervision, Software, Methodology, Investigation, Formal analysis.

机构署名：

本校为第一且通讯机构

院系归属：

第二中医临床医学院

摘要：

Psoriasis is a chronic inflammatory skin condition with high oxidative stress and immune dysregulation. Current therapies are limited by side effects and inefficacy over long-term use, highlighting the need for targeted treatments. This study investigates a reactive oxygen species (ROS)-responsive hydrogel (HP)-dissolving microneedle system, loaded with Momordin Ic, designed for controlled, site-specific release to alleviate psoriasis. We hypothesized that this system could target psoriatic inflammation by reducing pro-inflammatory cytokines an...

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Microneedle system carrying Momordin Ic-loaded ROS-responsive hydrogel ameliorates psoriasis via targeted anti-inflammatory and reactive oxygen species (ROS)-scavenging mechanisms

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