Eleutheroside K isolated from Acanthopanax henryi (Oliv.) Harms suppresses methicillin resistance of Staphylococcus aureus

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成果类型：

期刊论文

作者：

Li, Q. -Q.;Luo, J.;Liu, X. -Q.;Kwon, D. -Y.*;Kang, O. -H.

通讯作者：

Kwon, D. -Y.;Kang, OH

作者机构：

[Li, Q. -Q.; Kwon, D. -Y.; Kang, O. -H.; Kwon, DY] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Jeonbuk, South Korea.

[Li, Q. -Q.; Kwon, D. -Y.; Kang, O. -H.; Kwon, DY] Wonkwang Univ, Wonkwang Oriental Medicines Res Inst, Jeonbuk, South Korea.

[Liu, X. -Q.; Luo, J.] Hunan Univ Chinese Med, Sch Pharm, Changsha, Hunan, Peoples R China.

通讯机构：

[Kwon, DY; Kang, OH ] W

Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Jeonbuk, South Korea.

Wonkwang Univ, Wonkwang Oriental Medicines Res Inst, Jeonbuk, South Korea.

语种：

英文

关键词：

Electrophoresis;Medicine;Microwave integrated circuits;Proteins;Acanthopanax;Acanthopanax henryi(oliv.) harm;Anti-bacterial activity;Eleutheroside K;Eleutherosides;Methicillin;Methicillin-resistant staphylococcus aureus;Penicillin- binding proteins;Penicillin-binding protein 2a;Synergistic effect;Bacteria;ABC transporter;ampicillin;antibiotic agent;beta lactam antibiotic;ciprofloxacin;eleutheroside k;oxacillin;penicillin binding protein 2a;plant extract;unclassified drug;antiinfective agent;dicyclohexylcarbodiimide;eleutherosides;octoxinol;oxacillin;penicillin binding protein;plant extract;antibiotic resistance;bacterium;bioassay;concentration (composition);gene expression;isolated population;traditional medicine;Acanthopanax;Acanthopanax henryi;antibacterial activity;antibiotic resistance;Article;bacteriostatic activity;broth dilution;column chromatography;controlled study;fractional inhibitory concentration index;high performance liquid chromatography;inhibitory concentration;mass spectrometry;membrane permeability;methicillin resistance;methicillin resistant Staphylococcus aureus infection;minimum inhibitory concentration;nonhuman;nuclear magnetic resonance;plant leaf;polymerase chain reaction;Staphylococcus aureus;synergistic effect;biosynthesis;chemistry;combination drug therapy;down regulation;drug effect;drug potentiation;Eleutherococcus;metabolism;methicillin resistance;methicillin resistant Staphylococcus aureus;microbial sensitivity test;Acanthopanax;Bacteria (microorganisms);methicillin resistant Staphylococcus aureus;Ranellidae;Staphylococcus aureus;Anti-Bacterial Agents;Dicyclohexylcarbodiimide;Down-Regulation;Drug Synergism;Drug Therapy, Combination;Eleutherococcus;Methicillin Resistance;Methicillin-Resistant Staphylococcus aureus;Microbial Sensitivity Tests;Octoxynol;Oxacillin;Penicillin-Binding Proteins;Plant Extracts;Plant Leaves

期刊：

Letters in Applied Microbiology

ISSN：

0266-8254

年：

2021

卷：

期：

页码：

669-676

DOI：

10.1111/lam.13389

基金类别：

This study was supported by Wonkwang University in 2020.

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Acanthopanax (A.) henryi (Oliv.) Harms contain many bioactive compounds commonly used in traditional Chinese medicine. The objective of the present study was to investigate the antibacterial activity of the single constituent, Eleutheroside K (ETSK) isolated from the leaves of A. henryi (Oliv.) Harms, against methicillin-resistant Staphylococcus (S.) aureus (MRSA). Broth microdilution assay was used to measure the minimal inhibitory concentration (MIC) and the MIC values of ETSK against eight clinical S. aureus strains were all 50µgml−1. At s...

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Eleutheroside K isolated from Acanthopanax henryi (Oliv.) Harms suppresses methicillin resistance of Staphylococcus aureus

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