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Eleutheroside K isolated from Acanthopanax henryi (Oliv.) Harms suppresses methicillin resistance of Staphylococcus aureus

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成果类型:
期刊论文
作者:
Li, Q. -Q.;Luo, J.;Liu, X. -Q.;Kwon, D. -Y.*;Kang, O. -H.*
通讯作者:
Kwon, D. -Y.;Kang, O. -H.
作者机构:
[Kwon, DY; Kang, O. -H.; Li, Q. -Q.; Kwon, D. -Y.] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Jeonbuk, South Korea.
[Kwon, DY; Kang, O. -H.; Li, Q. -Q.; Kwon, D. -Y.] Wonkwang Univ, Wonkwang Oriental Medicines Res Inst, Jeonbuk, South Korea.
[Liu, X. -Q.; Luo, J.] Hunan Univ Chinese Med, Sch Pharm, Changsha, Hunan, Peoples R China.
通讯机构:
[Kwon, DY; Kang, OH] W
Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Jeonbuk, South Korea.
Wonkwang Univ, Wonkwang Oriental Medicines Res Inst, Jeonbuk, South Korea.
语种:
英文
关键词:
Acanthopanax henryi (Oliv;) Harms;antibacterial activity;Eleutheroside K;methicillin‐resistant Staphylococcus aureus;penicillin‐binding protein 2a;synergistic effect
期刊:
Letters in Applied Microbiology
ISSN:
0266-8254
年:
2021
卷:
72
期:
6
页码:
669-676
基金类别:
Wonkwang University
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Acanthopanax (A.) henryi (Oliv.) Harms contain many bioactive compounds commonly used in traditional Chinese medicine. The objective of the present study was to investigate the antibacterial activity of the single constituent, Eleutheroside K (ETSK) isolated from the leaves of A. henryi (Oliv.) Harms, against methicillin-resistant Staphylococcus (S.) aureus (MRSA). Broth microdilution assay was used to measure the minimal inhibitory concentration (MIC) and the MIC values of ETSK against eight clinical S. aureus strains were all 50 µg ml−1. At...

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