Eleutheroside K Isolated from Acanthopanax henryi (Oliv.) Harms Inhibits the Expression of Virulence-Related Exoproteins in Methicillin-Resistant Staphylococcus aureus
[Li, Qian-Qian; Kang, Ok-Hwa; Kwon, Dong-Yeul] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 54538, Jeonbuk, South Korea.
[Li, Qian-Qian; Kang, Ok-Hwa; Kwon, Dong-Yeul] Wonkwang Univ, Wonkwang Oriental Med Res Inst, Iksan 54538, Jeonbuk, South Korea.
[Liu, Xiang-Qian; Luo, Jiao] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Ok-Hwa Kang; Dong-Yeul Kwon] D
Department of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Iksan, Republic of Korea<&wdkj&>Department of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Iksan, Republic of Korea
Methicillin-resistant Staphylococcus (S.) aureus (MRSA) is a representative pathogen that produces numerous virulence factors involving manifold cytotoxins and exotoxins. The present study was designed to investigate the influence of Eleutheroside K (ETSK), a single compound isolated from the leaves of Acanthopanax (A.) henryi (Oliv.) Harms, on the exotoxins secreted by MRSA. The transcription and translation of the exotoxins (α-hemolysin and staphylococcal enterotoxins) related to virulence in S. aureus were determined via quantitative RT-PCR...
