期刊论文

Effects of Wenyang Zhenshuai granules on NT-pro BNP,IL-1,and IL-6 levels in rabbit model of chronic congestive heart failure

中文

湖南中医杂志

1003-7705

2014

30

11

151-153

10.16808/j.cnki.issn1003-7705.2014.11.075

国家自然科学基金资助项目（编号:81173213/H2708）； 湖南省科技厅科技计划项目（编号:2011FJ3042）； 湖南中医药大学校级青年基金项目（编号:99820001-103）；

本校为第一机构

目的：观察温阳振衰颗粒对阿霉素诱导性慢性心衰模型兔NT-pro BNP、IL-1及IL-6的影响。方法：健康新西兰兔35只,随机抽取5只为正常对照组,余30只兔耳缘静脉注射阿霉素4周后,进行心功能测定,按心功能分层随机分为模型对照组,温阳低、中、高剂量组和阳性对照组,各组用对应药物灌胃治疗,连续4周。治疗结束后比较各组模型兔氨基末端脑钠尿肽前体（NT-pro BNP）、白细胞介素-1（IL-1）、白细胞介素-6（IL-6）水平的变化。结果：与模型对照组比较,各治疗组NT-pro BNP、IL-1、IL-6水平均降低（P〈0.05）,且温阳高剂量组疗效优于中、低剂量组。结论：温阳振衰颗粒能降低心衰模型兔NT-pro BNP、IL-1及IL-...

Objective： To observe the effects of Wenyang Zhenshuai granules on N-terminal pro-brain natriuretic peptide（ NT-pro BNP）,interleukin-1（ IL-1）,and interleukin-6（ IL-6） levels in the rabbit model of chronic heart failure induced by adriamycin. Methods： Thirty-five healthy New Zealand rabbits were included in the study. Five rabbits were randomly selected from them as normal control group. The other 30 rabbits were given adriamycin injected into the auricular vein for 4 weeks and then underwent cardiac function test; stratified by the card...