期刊论文

中文

神经解剖学杂志

1000-7547

2011

27

4

365-370

国家自然科学基金（81070897）；

本校为其他机构

目的:探讨完全弗氏佐剂(complete Freund’sAdjuvant,CFA)致炎性疼痛后大鼠脊髓后角内ProBDNF及受体P75NTR和Sortilin的表达变化及意义。方法:大鼠随机分为正常组和实验组,实验组大鼠左侧足底皮下注射CFA和生理盐水混合溶剂100μ,l建立炎性疼痛模型,实验组包括注射CFA后6 h、1、3、7和14 d组。采用 Von Frey纤维测定不同时间点大鼠机械缩足阈值(pawwithdrawal threshold,PWT)的变化;采用免疫组织化学方法检测ProBDNF及P75NTR、Sortilin在脊髓后角的表达变化。结果:足底注射CFA后1 h PWT即下降,并在6 h后达到最低值,3 d后逐渐上调,至14 d仍低于基础值。ProBDNF在正常脊髓后角可见阳性表达;注射CF...

Objective： To explore expression changes of ProBDNF and its receptors P75NTR and Sortilin in posterior horn of the spinal cord followed by Complete Freund’s Adjuvant（CFA） induced inflammatory pain.Methods： Rats were received plantar subcutaneous injection of CFA and saline mixed solvent 100 μl,establishing inflammatory pain model.Rats were randomly divided into normal group and experimental group.The experimental group included rats with CFA injecyion at 6 h,1 d,3 d,7 d and 14 d.The change of paw withdrawal threshold（PWT） was observed b...