Metabolomics-based evidence of the hypoglycemic effect of Ge-Gen-Jiao-Tai-Wan in type 2 diabetic rats via UHPLC-QTOF/MS analysis

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期刊论文

作者：

Wang, Wenbo;Zhao, Linlin;He, Zhenyu;Wu, Ning;Li, Qiuxia;...

通讯作者：

Wang, DS

作者机构：

[Zhou, Lu; Wang, Wenbo; Li, Qiuxia; Qiu, Xinjian; Wang, Dongsheng; Wu, Ning] Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Changsha 410008, Hunan, Peoples R China.

[Zhao, Linlin] Cent South Univ, Xiangya Hosp 3, Phys Examinat Ctr, Changsha 410013, Hunan, Peoples R China.

[He, Zhenyu] Hunan Univ Tradit Chinese Med, Inst Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Wang, DS ] C

Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

alanine aminotransferase;antidiabetic agent;aspartate aminotransferase;bilirubin;chenodeoxycholic acid;Chinese drug;cholic acid;creatinine;Ge Gen Jiao Tai Wan;glucose;glycocholic acid;herbaceous agent;high density lipoprotein cholesterol;low density lipoprotein cholesterol;metformin;nitrogen;protein;taurine;taurochenodeoxycholic acid;taurocholic acid;triacylglycerol;unclassified drug;urea;uric acid;antidiabetic agent;herbaceous agent;jiao tai wan;alanine aminotransferase blood level;animal experiment;animal model;animal tissue;Article;aspartate aminotransferase blood level;bile acid blood level;bilirubin blood level;body weight;cholesterol blood level;controlled study;creatinine blood level;drug dose comparison;drug mechanism;drug megadose;histopathology;hyperglycemia;kidney function;liquid chromatography-mass spectrometry;liver function;low drug dose;male;metabolome;metabolomics;non insulin dependent diabetes mellitus;nonhuman;quadrupole mass spectrometry;rat;streptozotocin-induced diabetes mellitus;time of flight mass spectrometry;triacylglycerol blood level;upregulation;urea nitrogen blood level;uric acid blood level;animal;experimental diabetes mellitus;high performance liquid chromatography;metabolism;metabolomics;non insulin dependent diabetes mellitus;procedures;Sprague Dawley rat;tandem mass spectrometry;Animals;Chromatography, High Pressure Liquid;Diabetes Mellitus, Experimental;Diabetes Mellitus, Type 2;Drugs, Chinese Herbal;Hypoglycemic Agents;Male;Metabolomics;Rats;Rats, Sprague-Dawley;Tandem Mass Spectrometry

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2018

卷：

219

页码：

299-318

DOI：

10.1016/j.jep.2018.03.026

基金类别：

This research was supported by National Natural Science Foundation of China, China (No. 81173198 , 81373554 , 81703963 ), Scientifc Foundation of Hunan China ( 09JJ5055 ), and International Cooperation Program of the S & T Ministry, China ( 2010DFA32370 ). The authors are grateful to Mr. Jun-Liang Deng (Biotree Biotech Co., Ltd., Shanghai, China) for providing helps in data analysis.

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摘要：

Ethnopharmacological relevance: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional Chinese herbal medicine, is composed of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (Ge-Gen in Chinese), Coptis chinensis Franch (Huang-Lian), and Cinnamomum cassia (L.) J. Presl (Rou-Gui). GGJTW is used for treatment of diabetes in China, reflecting the potent hypoglycemic effect of its ingredients. However, little is known of the hypoglycemic effect of GGJTW and the underlying metabolic mechanism. Aim of the study: This study aimed to in...

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Metabolomics-based evidence of the hypoglycemic effect of Ge-Gen-Jiao-Tai-Wan in type 2 diabetic rats via UHPLC-QTOF/MS analysis

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