Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway

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成果类型：

期刊论文

作者：

Luo, Di-xian;Huang, Mei C.;Ma, Jun;Gao, Zachary;Liao, Duan-fang*;...

通讯作者：

Liao, Duan-fang

作者机构：

[Liao, Duan-fang; Luo, Di-xian] Univ S China, Coll Pharm & Life Sci, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Luo, Di-xian; Ma, Jun; Gao, Zachary; Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA.

[Huang, Mei C.] Mem Med Ctr, Dept Internal Med, Div Gastroenterol, Springfield, IL 62781 USA.

[Liao, Duan-fang] Hunan Univ Chinese Med, Sch Pharm, Dept Tradit Chinese Diagnost, Changsha 420108, Hunan, Peoples R China.

通讯机构：

[Liao, Duan-fang] U

Univ S China, Coll Pharm & Life Sci, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

aldo-keto reductase family 1;member B10 (AKR1B10);ATP-binding-cassette transporter (ABC transporter);calcium signalling;cancer marker;lysosomal exocytosis;non-classical protein-secretion pathway

期刊：

Biochemical Journal

ISSN：

0264-6021

年：

2011

卷：

438

期：

页码：

71-80

DOI：

10.1042/BJ20110111

基金类别：

National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [CA122622]; Department of DefenseUnited States Department of Defense [BC083555]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R21CA122622, R21CA122622] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

中医学院

药学院

摘要：

AKR1B10 (aldo-keto reductase family 1, member B10) protein is primarily expressed in normal human small intestine and colon, but overexpressed in several types of human cancers and considered as a tumour marker. In the present study, we found that AKR1B10 protein is secreted from normal intestinal epithelium and cultured cancer cells, as detected by a newly developed sandwich ELISA and Western blotting. The secretion of AKR1B10 was not affected by the protein-synthesis inhibitor cycloheximide and the classical protein-secretion pathway inhibito...

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Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway

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