Investigating the regulation mechanism of baicalin on triple negative breast cancer’s biological network by a systematic biological strategy

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成果类型：

期刊论文

作者：

Yang, Kailin;Zeng, Liuting;Ge, Anqi;Chen, Zhouhua;Bao, Tingting;...

通讯作者：

Ge, Jinwen;Huang, Lizhong

作者机构：

[Yang, Kailin] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing 100029, Peoples R China.

[Yang, Kailin] Capital Med Univ, Beijing, Peoples R China.

[Zeng, Liuting; Huang, Lizhong; Ge, Jinwen] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

[Ge, Anqi] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Chen, Zhouhua] Second Peoples Hosp Xiangtan City, Xiangtan, Hunan, Peoples R China.

通讯机构：

[Ge, JW; Huang, LZ] H

Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Baicalin;Triple negative breast cancer;Systematic biology;MDA-MB-231 cell;Real-time quantitative PCR

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

118

期：

118

页码：

109253

DOI：

10.1016/j.biopha.2019.109253

基金类别：

Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [12C1205]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ6080]; Key Project of Hunan Provincial Education DepartmentHunan Provincial Education Department [15A139]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81274008]

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

摘要：

Objective: To investigate the regulation mechanism of baicalin on triple negative breast cancer (TNBC)’s biological network by a systematic biological strategy and cytology experiment. Methods: A systematic biological methodology is utilized to predict the potential targets of baicalin, collect the genes of TNBC, and analyze the TNBC and baicalin's network. After the systematic biological analysis is performed, the cytology experiment, real-time quantitative PCR (qPCR) is used to validate the key biological processes and signaling pathways. Re...

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