Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1

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成果类型：

期刊论文

作者：

Li, Feng（李峰）;Li, Lanfang;Qin, Xuping;Pan, Weinan;Feng, Fen;...

通讯作者：

Chen, LX

作者机构：

[Li, Feng; Pan, Weinan; Li, Lanfang; Zhu, Bingyan; Qin, Xuping; Liao, Duanfang; Chen, Feng; Feng, Fen; Chen, Linxi] Nanhua Univ, Inst Pharmacol & Pharm, Hengyang 421001, Peoples R China.

[Tanowitz, Herbert] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.

[Albanese, Chris] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA.

[Albanese, Chris] Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.

[Li, Feng] Hunan Coll Tradit Chinese Med, Dept Physiol, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Chen, LX ] N

Nanhua Univ, Inst Pharmacol & Pharm, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Apelin;APJ;Cell cycle;Cyclin d1;Vascular smooth muscle

期刊：

FRONTIERS IN BIOSCIENCE-LANDMARK

ISSN：

2768-6701

年：

2008

卷：

期：

页码：

3786-3792

DOI：

10.2741/2967

基金类别：

NIAID NIH HHS [AI052739] Funding Source: Medline

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Apelin is the endogenous ligand of the G protein-coupled receptor, APJ. Vascular smooth muscle cells express both apelin and APJ, which are important regulatory factors in the cardiovascular and nervous systems. Importantly, APJ is also involved in the pathogenesis if HIV-1 infection. We investigated whether vascular smooth muscle cell proliferation was regulated through an apelin-pERK1/2-cyclin D1 signal transduction pathway. Apelin-13 significantly stimulated vascular smooth muscle cell proliferation and increased cell cycle progression. Apelin-13 a decreased the proportion of cell in the G0...

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Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1

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