Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1.

成果类型：

期刊论文

作者：

Li, Feng;Li, Lanfang;Qin, Xuping;Pan, Weinan;Feng, Fen;Chen, Feng;Zhu, Bingyan;Liao, Duanfang;Tanowitz, Herbert;Albanese, Chris;Chen, Linxi

通讯作者：

Chen, LX

作者机构：

[Chen, Linxi; Feng, Fen; Chen, Feng; Liao, Duanfang; Li, Feng; Qin, Xuping; Zhu, Bingyan; Li, Lanfang; Pan, Weinan] Nanhua Univ, Inst Pharmacol & Pharm, Hengyang 421001, Peoples R China.

[Li, Feng] Hunan Coll Tradit Chinese Med, Dept Physiol, Changsha 410007, Hunan, Peoples R China.

[Tanowitz, Herbert] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.

[Albanese, Chris] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA.

[Albanese, Chris] Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.

通讯机构：

[Chen, LX] Nanhua Univ, Inst Pharmacol & Pharm, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

apelin;APJ;cyclin D1;cell cycle;vascular smooth muscle

期刊：

Frontiers in bioscience : a journal and virtual library

ISSN：

1093-9946

年：

2008

卷：

13

页码：

3786-3792

文献类别：

WOS:Article

所属学科：

ESI学科类别:生物学与生物化学

入藏号：

WOS:000255885000048;PMID:18508473

DOI：

10.2741/2967

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Apelin is the endogenous ligand of the G protein-coupled receptor, APJ. Vascular smooth muscle cells express both apelin and APJ, which are important regulatory factors in the cardiovascular and nervous systems. Importantly, APJ is also involved in the pathogenesis if HIV-1 infection. We investigated whether vascular smooth muscle cell proliferation was regulated through an apelin-pERK1/2-cyclin D1 signal transduction pathway. Apelin-13 significantly stimulated vascular smooth muscle cell proliferation and increased cell cycle progression. Apelin-13 a decreased the proportion of cell in the G0/G1 phase while increasing the number of cells in S phase. Apelin-13 also increased the levels of cyclin D1, cyclin E and pERK1/2. Treatment of cells with the MEK inhibitor PD98059 attenuated the apelin-3-induced pERK1/2 activation. Similarly, treatment with PD98059 partially diminished the apelin-13-induced expression of cyclin D1 and vascular smooth muscle cell proliferation. Taken together, these data established that apelin-13 stimulates vascular smooth muscle cell proliferation by promoting the G1-S phase transition, and that this effect is mediated in part by an apelin-pERK1/2-cyclin D1 signal cascade.

参考文献：

ALBANESE C, 1995, J BIOL CHEM, V270, P23589

Ashley EA, 2005, CARDIOVASC RES, V65, P73, DOI 10.1016/j.cardiores.2004.08.018

Beltowski J, 2006, MED SCI MONITOR, V12, pRA112

CHAMLEYCAMPBELL J, 1979, PHYSIOL REV, V59, P1

Dai TY, 2006, EUR J PHARMACOL, V553, P222, DOI 10.1016/j.ejphar.2006.09.034

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