期刊论文

Effect on the Enzyme Activity of Paraoxonase 1 （PON-1） in the Experimental Atherosclerosis Rabbits Serum by Method of the Qi-Replenishing,Blood-Activating,Yang-Invigorating and Phlegm-resolving

中文

中国中医药现代远程教育

1672-2779

2014

12

6

148-149

10.3969/j.issn.1672-2779.2014.06.094

本校为第一机构

目的 观察益气活血、通阳化痰法对实验性动脉粥样硬化(AS)家兔血清对氧磷酶1 (PON-1)活性的影响.方法 将54只家兔随机分为6组,每组9只.分为空白对照组、模型对照组、辛伐他汀组、中药大、中、小剂量组.除空白对照组外其余各组给予高脂饲料喂养4周后开始灌胃给药,1次/d,连续4周后处死动物,测定血清PON-1活性.结果 模型组的PON-1活性较空白对照组明显降低(P＜0.01).中药各剂量组可以有效地升高血清PON-1活性,其中5g/kg剂量组和模型组比较差异十分明显(P＜0.01),2.5g/kg剂量组和模型组比较差异也有统计学意义(P＜0.05).结论 益气活血、通阳化痰法可通过升高血清PON-1活性来防治AS.

Objective To observe the effect of qi-replenishing, blood - activating, yang- invigorating and phlegm- resolving method on serum paraoxonase 1 （PON-1） activity of rabbits with experimental arteriosclerosis （AS）. Methods 54 rabbits were randomized equally into 6 groups, including blank control group, modeling group, therapy group with Simvastatin, and other 3 therapy groups with high, medium, low dosage o{ Chinese medicinal respectively. Rabbits from all groups, except blank control group, were fed with high fat diet for 4 weeks, and receive...