Oxymatrine ameliorates diabetes-induced aortic endothelial dysfunction via the regulation of eNOS and NOX4

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成果类型：

期刊论文

作者：

Wang, Lei;Li, Xinliang;Zhang, Yanqi;Huang, Yongpan;Zhang, Yinzhuang;...

通讯作者：

Ma, QL;Huang, YP

作者机构：

[Wang, Lei; Ma, Qilin; Zhang, Yinzhuang] Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China.

[Huang, Yongpan; Li, Xinliang] Hunan Acad Chinese Med, Inst Chinese Med, Dept Pharmacol, Changsha, Hunan, Peoples R China.

[Zhang, Yanqi] Guizhou Med Univ, Sch Stomatol, Dept Stomatol, Guiyang, Guizhou, Peoples R China.

[Huang, Yongpan] Changsha Social Work Coll, Sch Med, Dept Clin, Changsha, Hunan, Peoples R China.

[Huang, YP] Changsha Social Work Coll, Sch Med, Changsha 410006, Hunan, Peoples R China.

通讯机构：

[Huang, YP ; Ma, QL ] C

Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China.

Changsha Social Work Coll, Sch Med, Changsha 410006, Hunan, Peoples R China.

Hunan Acad Chinese Med, Inst Chinese Med, Changsha 410006, Hunan, Peoples R China.

语种：

英文

关键词：

diabetes;endothelial dysfunction;nitric oxide (NO);oxidative stress;oxymatrine (OMT)

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2019

卷：

120

期：

页码：

7323-7332

DOI：

10.1002/jcb.28006

基金类别：

This study was supported by the National Natural Science Foundation of China (No. 81370250) and Hunan Provincial Natural Science Foundation of China (No. 2017JJ2343, No. 2015SK2027, No. 2017SK50108).

机构署名：

本校为其他机构

院系归属：

中医学院

药学院

摘要：

AbstractAimOxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora ﬂavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In this study, we investigated the effects of OMT on diabetes‐associated aortic endothelial dysfunction in a rat model of diabetes and its mechanisms.MethodsMale Sprague‐Dawley rats were randomly divided into five groups: control, diabetic rats, diabetic rats treated with OMT (60, 120 mg/kg per day, by gavage), and diabetic rats treated with metformin (20 mg...

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Oxymatrine ameliorates diabetes-induced aortic endothelial dysfunction via the regulation of eNOS and NOX4

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