Scientific Research Projects of Education Department of Hunan Province [19B042]; Key R&D program of Hunan Province [2018SK1030]; Scientific Research Project of Health Commission of Hunan Province [20200853]
机构署名：
本校为其他机构
院系归属：
中医学院
摘要：
Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait and has been shown to exhibit a diverse range of pharmacological properties. The aim of the present study was to investigate the role of OMT in diabetic brain injury in vivo and in vitro. Diabetic rats were induced by intraperitoneal injection of a single dose of 65 mg/kg streptozotocin (STZ) and fed a high-fat and high-cholesterol diet. Memory function was assessed using a Morris water maze test. A SH-SY5Y cell injury model was induced by inc...
