[Huang, Yongpan] Changsha Social Work Coll, Med Sch, Dept Clin, Changsha, Hunan, Peoples R China.

[Huang, Yongpan; Li, Xinliang] Hunan Acad Chinese Med, Inst Chinese Med, Changsha, Peoples R China.

[Tang, Jiayu; Tang, JY; Zhang, Xi] Brain Hosp Hunan Prov, Dept Neurol, Changsha, Peoples R China.

[Tang, JY ] B

Brain Hosp Hunan Prov, Dept Neurol, Changsha, Peoples R China.

Brain;Cell death;Enzymes;Glucose;Insulin;Oxygen;Plants (botany);Polymerase chain reaction;Reactive oxygen species;Histological changes;Intraperitoneal injections;Morphological changes;Pharmacological properties;Quinolizidine alkaloids;Reverse transcription quantitative-PCR;Small interfering RNA;Superoxide dismutases;Rats;caspase 3;insulin;malonaldehyde;messenger RNA;neuroprotective agent;oxymatrine;protein S100B;reactive oxygen metabolite;reduced nicotinamide adenine dinucleotide phosphate oxidase;reduced nicotinamide adenine dinucleotide phosphate oxidase 2;reduced nicotinamide adenine dinucleotide phosphate oxidase 4;small interfering RNA;streptozocin;superoxide dismutase;alkaloid;Cybb protein, rat;Nox4 protein, rat;oxymatrine;quinolizine derivative;reduced nicotinamide adenine dinucleotide phosphate oxidase 2;reduced nicotinamide adenine dinucleotide phosphate oxidase 4;animal experiment;animal model;animal tissue;apoptosis;Article;biochemical analysis;brain cortex;brain tissue;cholesterol diet;controlled study;diabetic patient;electron microscopy;enzyme linked immunosorbent assay;fasting;gene expression level;gene knockdown;genetic transfection;glucose blood level;hyperglycemia;in vitro study;in vivo study;insulin blood level;learning test;lipid diet;male;memory disorder;Morris water maze test;neuropathology;neuroprotection;Nissl staining;non insulin dependent diabetes mellitus;nonhuman;oxidative stress;protein determination;protein expression;rat;real time reverse transcription polymerase chain reaction;SH-SY5Y cell line;transmission electron microscopy;TUNEL assay;upregulation;Western blotting;animal;apoptosis;brain;diabetic complication;drug effect;enzymology;experimental diabetes mellitus;genetics;memory disorder;metabolism;oxidative stress;pathology;Sprague Dawley rat;Damage;Dosage;Glucose;Inhibition;Oxygen;Staining;Stresses;Test Methods;Alkaloids;Animals;Apoptosis;Brain;Diabetes Complications;Diabetes Mellitus, Experimental;Male;Memory Disorders;NADPH Oxidase 2;NADPH Oxidase 4;Oxidative Stress;Quinolizines;Rats;Rats, Sprague-Dawley

中医学院