Effect and mechanism of Prunella vulgaris L. extract on alleviating lipopolysaccharide-induced acute mastitis in protecting the blood-milk barrier and reducing inflammation

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成果类型：

期刊论文

作者：

Luo, Hongshan*;Li, Yamei*;Xie, Jingchen*;Xu, Chunfang*;Zhang, Zhimin*;...

通讯作者：

Luo, Hongshan;Li, Yamei;Xie, Jingchen;Xu, Chunfang;Zhang, Zhimin;Li, Minjie;Xia, Bohou;Shi, Zhe;Lin, Limei

作者机构：

[Luo, Hongshan; Lin, Limei; Zhang, Zhimin; Li, Yamei; Xia, Bohou; Xu, Chunfang; Xie, Jingchen; Shi, Zhe; Li, Minjie] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China

[Luo, Hongshan] Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address: luohongshanxc@163.com

[Li, Yamei] Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address: yameili@hnucm.edu.cn

[Xie, Jingchen] Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address: 190478360@qq.com

[Xu, Chunfang] Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address: xcf200002@163.com

通讯机构：

[Limei Lin] C

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address:

语种：

英文

关键词：

Acute mastitis;Blood-milk barrier;Lipopolysaccharides;Prunella vulgaris L.

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2024

卷：

328

页码：

117998

DOI：

10.1016/j.jep.2024.117998

基金类别：

This work was supported by Hunan Province Science and Technology Innovation Leading Talent Project (Grant No: 2021RC4034); Hunan Science and Technology Innovation Team Project (Grant No: 2021RC4064); Hunan Provincial Natural Science Foundation (Grant No: 2022JJ80085); Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources (Grant No: 2060302). CRediT authorship contribution statement Hongshan Luo: Conceptualization, Data curation, Writing – original draft. Yamei Li: Conceptualization, Data curation, Writing – original draft. Jingchen Xie: Data curation, Formal analysis, Software. Chunfang Xu: Investigation. Zhimin Zhang: Validation. Minjie Li: Resources. Bohou Xia: Resources. Zhe Shi: Resources. Limei Lin: Conceptualization, acquisition, Resources, Supervision, Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: According to ancient literature, Prunella vulgaris L. (P vulgaris) alleviates mastitis and has been used in China for many years; however, there are no relevant reports that confirm this or the mechanism of its efficacy. AIM OF THE STUDY: To explore the anti-acute mastitis effect and potential mechanism of P vulgaris extract. MATERIALS AND METHODS: First, the active ingredients and targets of P vulgaris against mastitis were predicted using network pharmacology. Next, the relevant active ingredients were enriched...

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Effect and mechanism of Prunella vulgaris L. extract on alleviating lipopolysaccharide-induced acute mastitis in protecting the blood-milk barrier and reducing inflammation

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