Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway

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成果类型：

期刊论文

作者：

Xiong, Meng;Ou, Chen;Yu, Chang;Qiu, Jingyue;Lu, Jing;...

通讯作者：

Song, HP;Zeng, Meiyan

作者机构：

[Song, Houpan; Xiong, Meng; Qiu, Jingyue; Yu, Chang] Hunan Univ Chinese Med, Hunan Prov Key Lab Tradit Chinese Med Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Zeng, Meiyan; Song, Houpan; Xiong, Meng; Qiu, Jingyue; Yu, Chang; Fu, Chaojun] Hunan Univ Chinese Med, Sch Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Ou, Chen; Peng, Qinghua; Fu, Chaojun; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Hunan, Peoples R China.

[Lu, Jing] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zeng, MY; Song, HP ] H

Hunan Univ Chinese Med, Hunan Prov Key Lab Tradit Chinese Med Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Qi-Shen-Tang;Retinitis pigmentosa;NRF2;GPX4;ferroptosis

期刊：

Heliyon

ISSN：

2405-8440

年：

2023

卷：

期：

页码：

e22443

DOI：

10.1016/j.heliyon.2023.e22443

基金类别：

National Natural Science Foundation of China [82,004,427, 82,374,429]; Natural Science Foundation of Hunan Province [2023JJ30460, 2023JJ40474]; Science and Technology Innovation Program of Hunan Province [2021RC3101]; China Postdoctoral Science Foundation [2019M662790]; Key Project of Science Research of Hunan Provincial Education Department [21A0240, 22YS003]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Ferroptosis has been observed during retinal photoreceptor cell death, suggesting that it plays a role in retinitis pigmentosa (RP) pathogenesis. Qi-Shen-Tang (QST) is a combination of two traditional Chinese medicines used for the treatment of ophthalmic diseases; however, its mechanism of action in RP and ferroptosis remains unclear. Therefore, this study aimed to explore the effect and potential molecular mechanisms of QST on RP. QST significantly improved tissue morphology and function of the retina in the RP model mice. A significant increase in retinal blood flow and normalization of the...

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Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway

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