期刊论文

Zeng, PH

英文

Molecular Biotechnology

1073-6085

2025

1-19

10.1007/s12033-025-01444-2

This work was supported by the National Natural Science Foundation of China (82074425); the Hunan Province key research and development project (2023SK2057); the Hunan Provincial Natural Science Foundation (2023JJ40403, 2025JJ30038); the Hunan Provincial Administration of Traditional Chinese Medicine Research Project (B2023089); the Graduate Student Innovation Project of Hunan University of Chinese Medicine (2023CX113).

本校为第一且通讯机构

This study explores the diagnostic and therapeutic potential of SCN5A, an immunogenic cell death (ICD)-related gene, in hepatocellular carcinoma (HCC). Integrated analysis of four databases identified 62 ICD-associated genes (ICDGs), with SCN5A emerging as a key player linked to HCC prognosis and immune microenvironment modulation. Single-cell RNA sequencing revealed correlations between ICD activity and tumor immune dynamics. Bulk RNA sequencing categorized HCC into distinct molecular subtypes with varied immunological features. Machine learning-based prognostic models highlighted SCN5A's cli...